The Hooks et al. review of microbiota-gut-brain literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: highlighting capabilities of advanced systems-biology “-omics” techniques for microbiome research and recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.

The Madhyamaka Buddhist philosopher Nāgārjuna (2nd c. CE) is best known for his works on emptiness in which he advances a program for the relinquishing of all philosophical views (_dṛṣṭi_) in light of the impossibility of establishing the true existence of any kind of entity. At the same time, he is famous also for his theory of two truths, according to which conventional or transactional language is both a legitimate and a necessary factor on the path to the ultimate abandonment (...) of views. Although more than 100 works are ascribed to Nāgārjuna in the Tibetan canon, none is specifically dedicated to an exploration of conventional or transactional truth. So it is of great interest to find that two eighth-century Madhyamaka thinkers, Śāntarakṣita and Kamalaśīla, have in their writings preserved and commented on six verses from a treatise they ascribe to Nāgārjuna entitled _Establishing the Transactional_ (_Tha snyad grub pa = *Vyavahārasiddhi_). The present article provides a translation of the six verses from the Tibetan (the Sanskrit of all these writings is lost) along with a translation for the first time in English of Śāntarakṣita’s commentary and Kamalaśīla’s subcommentary upon the verses. The multi-part translation is framed by a consideration of the nature and role of philosophical views in relation to Nāgārjuna’s other writings, based on a reading of these few tantalizing verses from an apparently lost text, the commentaries of Śāntarakṣita and Kamalaśīla, and the theories of contemporary Madhyamaka scholars. (shrink)

As it stands, Derrida’s protest is deficient in any sense of how the discourses of South African racism have been at once historically constituted and politically constitutive. For to begin to investigate how the representation of racial difference has functioned in South Africa’s political and economic life, it is necessary to recognize and track the shifting character of these discourses. Derrida, however, blurs historical differences by conferring on the single term apartheid a spurious autonomy and agency: “The word concentrates separation…. (...) By isolating being apart in some sort of essence or hypostasis, the word corrupts it into a quasi-ontological segregation” . Is it indeed the word, apartheid, or is it Derrida himself, operating here in “another regime of abstraction” , removing the word from its place in the discourse of South African racism, raising it to another power, and setting separation itself apart? Derrida is repelled by the word, yet seduced by its divisiveness, the division in the inner structure of the term itself which he elevates to a state of being.The essay’s opening analysis of the word apartheid is, then, symptomatic of a severance of word from history. When Derrida asks, “Hasn’t apartheid always been the archival record of the unnameable?” , the answer is a straightforward no. Despite its notoriety and currency overseas, the term apartheid has not always been the “watchword” of the Nationalist regime. . It has its own history, and that history is closely entwined with a developing ideology of race which has not only been created to deliberately rationalize and temper South Africa’s image at home and abroad, but can also be seen to be intimately allied to different stages of the country’s political and economic development. Because he views apartheid as a “unique appellation” , Derrida has little to say about the politically persuasive function that successive racist lexicons have served in South Africa. To face the challenge of investigating the strategic role of representation, one would have to part ways with him by releasing that pariah of a word, apartheid, from its quarantine from historical process, examining it instead in the context of developing discourses of racial difference. Anne McClintock is a Ph.D. candidate in English at Columbia University. She is working on a dissertation on race and gender in British imperial culture and is the author of a monograph on Simon de Beauvoir. Rob Nixon, in the same program at Columbia, is working on the topic of exile and Third World-metropolitan relations in the writing of V. S. and Shiva Naipaul. (shrink)

The great Buddhist writer Santaraksita (725-88) was central to the Buddhist traditions spread into Tibet. He and his disciple Kamalasila were among the most influential thinkers in classical India. They debated ideas not only within the Buddhist tradition but also with exegetes of other Indian religions, and they both traveled and nurtured Buddhism in Tibet during its infancy there. Their views, however, have been notoriously hard to classify. The present volume examines Santaraksita's encyclopedic Tattvasamgraha and Kamalasila's detailed commentary on that (...) text in his Panjika, two works that have historically been presented together. The works cover all conceivable problems in Buddhist thought and portray Buddhism as a supremely rational faith. One hotly debated topic of their time was omniscience -- infinite, all-compassing knowledge -- whether it was possible and whether one could defensibly claim it as a quality of the Buddha. (shrink)

While a growing body of scholarship identifies urban agriculture’s broad suite of benefits and drivers, it remains unclear how motivations to engage in urban agriculture (UA) interrelate or how they differ across cities and types of organizations. In this paper, we draw on survey responses collected from more than 250 UA organizations and businesses from 84 cities across the United States and Canada. Synthesizing the results of our quantitative analysis of responses (including principal components analysis), qualitative analysis of textual data (...) excerpted from open-ended responses, and a review of existing literature, we describe six motivational frames that appear to guide organizations and businesses in their UA practice: Entrepreneurial, Sustainable Development, Educational, Eco-Centric, DIY Secessionist, and Radical. Identifying how practitioners stack functions and frame their work is a first step in helping to differentiate the diverse and often contradictory efforts transforming urban food environments. We demonstrate that a wide range of objectives drive UA and that political orientations and discourses differ by geography, organizational type and size, and funding regime. These six paradigms provide a basic framework for understanding UA that can guide more in-depth studies of the gap between intentions and outcomes, while helping link historically and geographically specific insights to wider social and political economic processes. (shrink)

Traditional as well as contemporary interpreters of Indian Yogācāra divide that tradition into a variety of doxographical camps depending on whether awareness is understood tobe endowed with phenomenal content (ākāra) and, if so, whether that content is understood to be real or true. Kamalaśīla’s extensive commentary on his teacher Śāntarakṣita’s Tattvasaṃgraha contains passages that throw into question certain doxographical equivalencies, especially the equivalencies sometimes proposed betweenthe doctrine that awareness is endowed with phenomenal content (sākāravāda) and the doctrine that such content (...) is true or real (satyākāravāda) and between the doctrine that awareness is devoid of phenomenal content (nirākāravāda) and the doctrine that such content is false or unreal (alīkākāravāda). Further, in accord with his broadly rhetorical approach to the application of reason, Kamalaśīla is seen in this commentary to endorse a range of seemingly contradictory positions vis-à-vis ākāra. This article argues that this situation can be explained by way of reference to Kamalaśīla’s larger philosophical and soteriological program as a Mādhyamika thinker, a program not made explicit in the text yet nonetheless present in nascent form. That is, while various theories of awareness as endowed or not endowed with phenomenal content are useful in different rhetorical contexts as well as at different stages of philosophical analysis, at the end of the day such distinctions are moot since neither awareness nor its content is upheld as ultimately real. Instead, soteriologically efficacious phenomenal content is said to be like a “true dream” (satyasvapna), an illusion that satisfies only for as long as it remains unanalyzed. (shrink)

Although rhetoric is not a category of ancient Indian philosophy, this paper argues that Śāntarakṣita and Kamalaśīla, 2 eighth-century Indian Buddhist philosophers, can nonetheless be seen to embrace a rhetorical conception of rationality. That is, while these thinkers are strong proponents of rational analysis and philosophical argumentation as tools for attaining certainty, they also uphold the contingent nature of all such processes. Drawing on the categories of the New Rhetoric, this paper argues that these Buddhist thinkers understand philosophical argumentation to (...) be directed at a universal audience of rational beings, where this universal audience is not an actual audience but a rhetorical one constructed through the author’s particular and historically contingent conception of what counts as rational. A reception theory of rationality is one that holds that the rationality of an argument depends upon its acceptance by a rational audience. When philosophers recognize the historically contingent nature of what counts as rational, they can embrace a reception theory of rationality that neither reduces the rational to mere opinion nor restricts it to a single, absolute, and timeless standard. (shrink)

On the winter morning of 16 June 1976, fifteen thousand black children marched on Orlando Stadium in Soweto, carrying slogans dashed on the backs of exercise books. The children were stopped by armed police who opened fire, and thirteen-year-old Hector Peterson became the first of hundreds of schoolchildren to be shot down by police in the months that followed. If, a decade later, the meaning of Soweto’s “year of fire” is still contested,1 it began in this way with a symbolic (...) display of contempt for the unpalatable values of Bantu education, a public rejection of the “culture of malnutrition” with which blacks had been fed.2 The local provocation for the Orlando march was a ruling that black children be taught arithmetic and social studies in Afrikaans—the language of the white cabinet minister, soldier, and pass official, prison guard, and policeman. But the Soweto march sprang from deeper grievances than instruction in Afrikaans, and the calamitous year that passed not only gave rise to a rekindling of black political resistance but visibly illuminated the cultural aspects of coercion and revolt.The children’s defacement of exercise books and the breaking of school ranks presaged a nationwide rebellion of uncommon proportion. The revolt spread across the country from community to community, in strikes, boycotts, and street barricades. It represented in part the climax of a long struggle between the British and Afrikaans interlopers for control over an unwilling black populace and was at the same time a flagrant sign of the contestation of culture, an open declaration by blacks that cultural value, far from shimmering out of reach in the transcendent beyond, would now be fought for with barricades of tires, empty classrooms, and precocious organization. 1. At least three general analyses of the Soweto uprising have emerged: deeper African National Congress involvement in the community; strains on the educational system, unemployment and recession, with greater industrial militancy stemming from the strikes in the early seventies; and the emergence of Black Consciousness ideology. See Tom Lodge, Black Politics in South Africa Since 1945 , pp. 321-62.2. See M. K. Malefane, “ ‘The Sun Will Rise’: Review of the Allahpoets at the Market Theatre, Johannesburg,” Staffrider ; reprinted in Soweto Poetry, ed. Michael Chapman, South African Literature Studies, no. 2 , p. 91. Soweto Poetry will hereafter be cited as SP. Anne McClintock is a Ph.D. candidate in English at Columbia University. She is the author of a monograph on Simone de Beauvoir and is working on a dissertation on race and gender in British imperial culture. Her previous contribution to Critical Inquiry , “No Names Apart: The Separation of Word and History in Derrida’s ‘Le Dernier Mot du Racisme,’ ” appeared in the Autumn 1986 issue. (shrink)

Since the Nuremberg trials (1947–1949), informed consent has become central for ethical practice in patient care and biomedical research. Codes of ethics emanating from the Nuremberg Code (1947) recognize the importance of protecting patients and research subjects from abuses, manipulation and deception. Informed consent empowers individuals to autonomously and voluntarily accept or reject participation in either clinical treatment or research. In some cases, however, the underlying mental or physical condition of the individual may alter his or her cognitive abilities and (...) compromise the informed consent process. This is particularly true in chronic psychiatric conditions such as Treatment-Resistant Depression (TRD), where individuals may fail to respond to traditional antidepressant treatments (e.g., psychotherapy, pharmacotherapy). Moreover, it may raise further concerns for an individual’s motivation to consent and the level of understanding of the treatment or research procedure. This paper focuses on the informed consent process for Vagus Nerve Stimulation (VNS) in the treatment of individuals diagnosed with TRD. Specifically, the paper addresses how depression may affect the decision-making capacity of an individual and the potential ethical and legal impact of failure to appreciate the seven elements of the consenting process (competence, voluntariness, disclosure, recommendation, understanding, decision, and authorization). To ensure the protection of vulnerable individuals with psychiatric disorders such as TRD and promote ethical behavior in biomedical research and patient care while avoiding potential legal pitfalls, we propose a paradigm that requires a stringent evaluation process of decision-making capacity for informed consent. (shrink)

In the December 2006 edition of Harvard Business Review , Michael Porter and Mark Kramer argue that by approaching corporate social responsibility (CSR) based on corporate priorities, strengths and abilities, firms can develop socially and fiscally responsible solutions to current CSR issues, which will provide operational and competitive advantages. We agree that an effective approach to CSR includes a mapping of strategy, risk and opportunity. However, we also caution that the identification of these to the exclusion of societal input may (...) not be to the corporation's advantage. Instead, an investment in both strategic analysis and social capital can pay off from a social and an organizational standpoint. Compared with their larger counterparts, small- and medium-sized enterprises (SMEs) frequently have stronger relationships with their internal and external stakeholders that foster the development of social capital. As such, we believe that the sector offers a unique opportunity to identify additional models and frameworks in order to approach a strategic CSR model as espoused by Porter and Kramer. This paper explores a case study of one Canadian SME that uses a community development framework called Asset Based Community Development (ABCD) for its CSR programming. Because ABCD relies heavily on the development and maintenance of social capital and can be utilized to attain set objectives, we propose that it provides a supplementary framework through which the arguments of Porter and Kramer can be expanded. In applying the ABCD framework for CSR, we can begin to establish a programme that supports strategy, integrates employees and stakeholders towards a common vision, and creates unique and sustainable alternatives towards the resolution of social and corporate goals. (shrink)

This volume explores how Catholicism began and continues to open its doors to the wider world and to other confessions in embracing ecumenism, thanks to the vision and legacy of the Second Vatican Council. It explores such themes as the twentieth century context preceding the council; parallels between Vatican II and previous councils; its distinctively pastoral character; the legacy of the council in relation to issues such as church-world dynamics, as well as to ethics, social justice, economic activity. Several chapters (...) discuss the role of women in the church before, during, and since the council. Others discern inculturation in relation to Vatican II. The book also contains a wide and original range of ecumenical considerations of the council, including by and in relation to Free Church, Reformed, Orthodox, and Anglican perspectives. Finally, it considers the Council’s ongoing promise and remaining challenges with regard to ecumenical issues, including a groundbreaking essay on the future of ecumenical dialogue by Cardinal Walter Kasper. (shrink)

Barbara McClintock (1902–1992), the renowned American maize geneticist, received the 1983 Nobel Prize “for her discovery of mobile genetic elements,” becoming the seventh woman scientist to receive a Nobel Prize. However, Nathaniel Comfort points out that McClintock viewed her primary contribution as the elucidation of control systems, rather than the discovery of mobile elements. McClintock’s interest in control systems dates back to the 1940s, and this paper investigates her 1961 conversation with François Jacob and Jacques Monod, where (...) she sought to shape the interpretation of her work by drawing parallels between maize control systems and a bacterial system they had recently discovered. Despite McClintock’s efforts, Jacob and Monod rejected her parallels and suggested that her contribution was limited to mobile elements. Through an examination of their published papers, I argue that Jacob and Monod’s rejection stemmed from their failure to fully comprehend maize control systems. Disciplinary discrepancy helps explain Jacob and Monod’s lack of comprehension: they were molecular geneticists working on bacteria, while McClintock was a classical geneticist studying maize. I further argue that gender played a role, as McClintock experienced the Matilda effect—the under-recognition of her contribution, reinforced by the reactions of two male geneticists, and ironically, by the award of the Nobel Prize. Control systems, stemming from McClintock’s reverence for organisms, embodied what Evelyn Fox Keller defines as “gender-neutral science.” This divergent view of science provides insight into why Jacob and Monod failed to grasp McClintock’s work in 1961. (shrink)

In the standard narrative of her life, Barbara McClintock discovered genetic transposition in the 1940s but no one believed her. She was ignored until molecular biologists of the 1970s "rediscovered" transposition and vindicated her heretical discovery. New archival documents, as well as interviews and close reading of published papers, belie this narrative. Transposition was accepted immediately by both maize and bacterial geneticists. Maize geneticists confirmed it repeatedly in the early 1950s and by the late 1950s it was considered a (...) classic discovery. But for McClintock, movable elements were part of an elaborate system of genetic control that she hypothesized to explain development and differentiation. This theory was highly speculative and was not widely accepted, even by those who had discovered transposition independently. When Jacob and Monod presented their alternative model for gene regulation, the operon, her controller argument was discarded as incorrect. Transposition, however, was soon discovered in microorganisms and by the late 1970s was recognized as a phenomenon of biomedical importance. For McClintock, the award of the 1983 Nobel Prize to her for the discovery of movable genetic elements, long treated as a legitimation, may well have been bittersweet. This new look at McClintock's experiments and theory has implications for the intellectual history of biology, the social history of American genetics, and McClintock's role in the historiography of women in science. (shrink)

Barbara McClintock won the Nobel Prize in 1983 for her discovery of mobile genetic elements. Her Nobel work began in 1944, and by 1950 McClintock began presenting her work on "controlling elements." McClintock performed her studies through the use of controlled breeding experiments with known mutant stocks, and read the action of controlling elements (transposons) in visible patterns of pigment and starch distribution. She taught close colleagues to "read" the patterns in her maize kernels, "seeing" pigment and (...) starch genes turning on and off. McClintock illustrated her talks and papers on controlling elements or transposons with photographs of the spotted and streaked maize kernels which were both her evidence and the key to her explanations. Transposon action could be read in the patterns by the initiated, but those without step by step instruction by McClintock or experience in maize often found her presentations confusing. The photographs she displayed became both McClintock's means of communication, and a barrier to successful presentation of her results. The photographs also had a second and more subtle effect. As images of patterns arrived at through growth and development of the kernel, they highlight what McClintock believed to be the developmental consequences of transposition, which in McClintock's view was her central contribution, over the mechanism of transposition, for which she was eventually recognized by others. Scientific activities are extremely visual, both at the sites of investigation and in communication through drawings, photographs, and movies. Those visual messages deserve greater scrutiny by historians of science. (shrink)

This is a critique of the idea of universality in art and science that considers the examples of Georgia O'Keeffe's work as an artist and Barbara McClintock's work as a scientist. A consideration of their lives and work brings out their differences in the inherently male fields of art and science. Their underlying commonality is found in a shared view of nature involving fluidity, concern for detail, and caring and feeling, traits often characterized as "female". This enables each of (...) them to assert her own identity in her work and contributes to its remarkable success. (shrink)

Fred. L. Polak explored the mechanisms of social change in terms of “future—visions” held by a community. The future, says Polak, participates actively in the present, providing part of the context within which today's decisions are made. Barbara McClintock acquired her insights in maize genetics by developing “a feeling for the organism.” New insights, she maintains, emerge through a mutual relationship between researcher and subject. Though scholars in different fields, both acknowledge the power of images in the creative process. (...) There is a difference in the extent to which each scientist perceives this power to be available to create new ideas. (shrink)

A persistent puzzle for philosophers of science is the well-documented appeal made by scientists to their aesthetic emotions in the course of scientific research. Emotions are usually viewed as irremediably subjective, and thus of no epistemological interest. Yet, by denying an epistemic role for scientists’ emotional dispositions, philosophers find themselves in the awkward position of ignoring phenomena which scientists themselves often insist are of importance. This paper suggests a possible solution to this puzzle by challenging the wholesale identification of emotion (...) with subjectivity. The proposed method is a naturalistic and externalist one, calling for empirical investigation into the intersubjective processes by which scientists’ emotional dispositions become refined and attuned to specific objects of attention. The proposal is developed through a critical discussion of Michael Polanyi’s theory of scientific passions, as well as plant geneticist Barbara McClintock’s celebrated “feeling for the organism.”. (shrink)

Interviewing offers the biographer unique opportunities for gathering data. I offer three examples. The emphatic bacterial geneticist Norton Zinder confronted me with an interpretation of Barbara McClintock's science that was as surprising as it proved to be robust. The relaxed setting of the human geneticist Walter Nance's rural summer home contributed to an unusually improvisational oral history that produced insights into his experimental and thinking style. And "embedding" myself with the biochemical geneticist Charles Scriver in his home, workplace, and (...) city enabled me to experience the social networks that drive the practical events of his career, which in turn helped me explain the theoretical basis of his science. Face-to-face interaction and multisensory experience will shape each biographer's experience uniquely. Recent developments in sensory physiology suggest that the experience of integrating sense data encourages different patterns of observation and reflection. It is reasonable, then, to think that biography based on face-to-face interviews will, for a given author, have a different character than one based entirely on documents. I reflect on how interviewing shapes my own writing and I encourage the reader to do the same. (shrink)

Contemporary educational policies have recently prioritised the development of generic, core, and transferable skills. This essay reflects on this tendency in the context of the ‘algorithmic condition’ and those discourses that tend toward an image of education that privileges dematerialised skills, practices, and knowledge. It argues that this turn towards dematerialisation is resonant with shifts in a number of diff erent domains, including work, and explores some of the implications of this shift. Instead I suggest an approach to education that (...) understands it as turning towards the world, loving the world, and creating a common world. In order to understanding thinking and knowing as material practices, the concept of ‘material thinking’ is developed that refuses binaries of theory and practice, but that instead understands thinking, particularly in educational contexts, as material and a practice of thinking with something, and a turning towards the world. I draw upon the work of Susan Oyama, Elizabeth Grosz, Tim Ingold and Isabelle Stengers, and explore the example of Barbara McClintock’s research as a cytogeneticist researching maize. Here I am particularly interested in the importance of deep engagement with a subject matter in terms of developing the skilfulness that is associated with what I am calling ‘material thinking’. This allows us to think about education in a way that pays attention to the plurality of practices of material thinking that engage with the natural history of humankind, and the story of the world. (shrink)

Evolution is frequently concentrated in bursts of rapid morphological change and speciation followed by long‐term stasis. We propose that this pattern of punctuated equilibria results from an evolutionary tug‐of‐war between host genomes and transposable elements (TEs) mediated through the epigenome. According to this hypothesis, epigenetic regulatory mechanisms (RNA interference, DNA methylation and histone modifications) maintain stasis by suppressing TE mobilization. However, physiological stress, induced by climate change or invasion of new habitats, disrupts epigenetic regulation and unleashes TEs. With their capacity (...) to drive non‐adaptive host evolution, mobilized TEs can restructure the genome and displace populations from adaptive peaks, thus providing an escape from stasis and generating genetic innovations required for rapid diversification. This “epi‐transposon hypothesis” can not only explain macroevolutionary tempo and mode, but may also resolve other long‐standing controversies, such as Wright's shifting balance theory, Mayr's peripheral isolates model, and McClintock's view of genome restructuring as an adaptive response to challenge. (shrink)

Urban agriculture is a promising avenue for food system change; however, projects often struggle with a lack of volunteers—limiting both their immediate goals and the broader movement-building to which many alternative food initiatives (AFIs) aspire. In this paper, I adopt a case study approach focusing on Farm X, an urban farm with a strong volunteer culture located in Tāmaki-Makaurau Auckland, New Zealand’s largest city. Drawing on a significant period of researcher participation and 11 in-depth interviews with volunteers and project coordinators, (...) I first contextualise and explore the history of Farm X, then offer themes to describe key factors which help or hinder their volunteer engagement. Engagement is helped by strong leadership, learning by doing, socialising around plants, and contributing to a movement. Conversely, engagement is hindered by time scarcity, economic hurdles, and struggles over direction. Drawing on McClintock’s (Local Environ 19(2): 147–171, 2014, 10.1080/13549839.2012.752797) insights into the hybrid and contradictory nature of urban agriculture as a tool for social change, the paper continues with a discussion of two important trade-offs involved in both farm management and the movement building promoted by Farm X: focused leadership verses volunteer agency; and asking more verses less of volunteers. Finally, I suggest several avenues that may be useful for other urban agriculture projects interested in movement building. (shrink)

Correction to: Maria Santesmases, "Women in Early Human Cytogenetics: An Essay on a Gendered History of Chromosome Imaging," in the special issue, "Heredity and Evolution in an Ibero-American Context," Perspectives on Science 28 : 170–200. In this article, on page 177, in the sentence beginning: "Among these was Barbara McClintock," the date of McClintock's publication should read "1930". On page 178, the caption of Figure 4 should read: "From McClintock 1930, pp. 792, 793; reproduced with permission...." To (...) the References, on page 197, should be added: "McClintock, Barbara. 1930. "A cytological demonstration of the location of an interchange between two non-homologous chromosomes of Zea... (shrink)

In developing theologies and spiritualities of ecology, Christians can learn from the Nobel laureate Barbara McClintock and from process theology. That “feeling for the organism” of which McClintock speaks can be understood within a process context as a distinctive mode of spirituality. The feeling is an intuitive and sympathetic apprehension of another creature in a way which mirrors God’s own way of perceiving. It involves feeling the other creature as a fellow subject with intrinsic value. A subjective capacity (...) of this sort is by no means sufficient for a spirituality of ecology, but by all means necessary. (shrink)

Although more than thirty years of intensive investigation have passed since McClintock first published results on menstrual synchrony, there is still no conclusive evidence for the existence of this phenomenon. Indeed, a growing body of nullresult studies, critiques of menstrual synchrony studies, and the lack of convincing evolutionary explanations bring into question the existence of this phenomenon. This paper presents results of a study conducted over five consecutive months in Polish student dormitories. In 18 pairs and 21 triples of (...) college-age women, menstrual synchrony was not found. Social interactions, considered the most important factor mediating the effect of menstrual synchrony, was unrelated to any difference in menstrual cycle onsets. Initial menstrual onset difference was influenced by woman’s body mass and menstrual cycle irregularity. These results provide further evidence that women do not synchronize their menstrual cycles. (shrink)

“Evolvability,” writes Evelyn Fox Keller, “refers to the capacity to generate any kind of heritable phenotypic variation upon which selection can act” . Whether one considers genes or organisms, the potential to adapt and evolve, to respond flexibly to a changing environment, is now recognized by many biologists as itself a trait actively favored by natural selection. Keller correctly presents this idea as an antidote to an old notion of genetic stability. She seems not to appreciate how well it applies (...) to her own subject.The Century of the Gene is Keller's latest collection of linked essays, six tidy, intelligent shovelfuls from her ongoing effort to undermine the claims of mainstream molecular biology and to substitute from the scientific margins an alternative interpretation. This project stems from her philosophical biography of the geneticist Barbara McClintock, published in 1983. In her Nobel speech, also from 1983, McClintock wrote of the genome as a dynamic “sensitive organ of the cell,” responsive, flexible, and interacting with the environment. For half a century, McClintock had railed at biologists that genes must be studied not as autonomous, independently acting units but rather as parts of an exquisite whole, acting in concert. Keller celebrated this in McClintock's work, though many have read Keller as applying to this view of nature a gloss of feminism that McClintock rejected. More recently, among other projects, Keller has criticized the “master molecule” concept in biology, examined the use of metaphor in science, and celebrated Christiane Nüsslein‐Vollhard's studies in developmental biology. Through it all, she maintains a fascination with gender and with language as shapers of scientific thought.Here Keller explores what she sees as the divergent histories of studies of genes and use of the term “gene.” While scientists continue to talk of genes much as they have done for a century now—as stable, discrete units directing the activities of the cell and the development of the organism—the molecular biology of the last forty years has seen a breaking down of the boundaries of the gene, physically, chemically, and physiologically. Keller begins by attacking the notion of genetic stability—whence the introductory quotation about evolvability. Next she explores the idea of genetic regulation, the fact that genes do not make anything, nor do they literally control anything. The molecular biologist's version of the chicken‐and‐egg problem is: Which comes first—proteins or genes? Proteins read the DNA that provides the instructions to make more proteins. Keller argues for chickens.The most important idea in the book is Keller's distinction between a developmental program and a genetic program. The former is a sequence of ontological steps in the life of an organism; it does not presuppose that all steps in the program are encoded in genes or that all steps are determined prior to the beginning of development. Developmental programs may be derived empirically, independently of genetic analysis. In contrast, the genetic program is a more recent idea that does locate the program instructions in the nucleus in the fertilized egg. For Keller, genetic programs carry implications of determinism, a restriction of vision in our attempts to understand nature.The term “gene,” Keller concludes, has outlived its utility. Molecular biologists no longer work with anything so discrete as genes. Their own data, she argues, show that genes and genomes are flexible, modular, and interactive. Keller wishes for, but does not offer, a new term or set of terms that would better reflect current understanding of genetics and development.If biologists have shown that the gene concept is outmoded, why don't they know it? Keller's answer is that the biologists have not yet recognized the implications of their own results; their language lags behind their knowledge. Eventually, she believes, either they will drop the term “gene” or biology must suffocate in its shell. Yet the changes she describes have been under way for decades and biology shows no signs of slowing. Keller recognizes this, and in the conclusion she briefly acknowledges the obvious solution to the conundrum: that biology continues to grow because of, not despite, this linguistic flexibility. This important idea deserves fuller treatment.As with the gene in nature, so with the word “gene” in the scientific lexicon: its very evolvability is selected for, a crucial trait that ensures its survival. (shrink)

The aim of the present study was to investigate the effect of the “Visual Awareness Education Programme” developed to support the visual literacy skills of preschool children. The study group comprised 40 children (20 children in the experimental group and 20 children in the control group) attending preschool in the 2014–2015 school year. The pre-test post-test experimental model was used in the study. The “Visual Literacy Inventory for Preschool Children” and the “Children’s Visual Literacy Rating Inventory for Parents” were used (...) to determine visual literacy level of children. Study results revealed significant differences in favour of the experimental group children in the sub-dimensions and the post-test scores of the “Visual Literacy Inventory for Preschool Children” and the post-test scores of the “Children’s Visual Literacy Rating Inventory for Parents”. (shrink)

Мета. Стаття являє собою філософсько-антропологічну репрезентацію ідеї духовності в трилогії "Фундація" американського письменника-фантаста, філософа, популяризатора науки Айзека Азімова. Теоретичний базис. Дослідження базується на розумінні світоглядних імперативів творчості А. Азімова, які висвітлюють його філософсько-антропологічне бачення духовності як історично усталеної властивості раціонально організованого суспільства і ключову умову його прогресивної еволюції. Емерджентність, стохастичність і евентуальність розвитку сучасного глобального соціуму виводить зміст філософсько-антропологічних ідей А. Азімова на принципово новий рівень розуміння подальшого розвитку людства. Артикуляція А. Азімовим ідеї духовності в трилогії "Фундація" дозволяє визначити філософсько-антропологічну (...) концепцію письменника у всій повноті її соціального, філософського, екзистенціального та аксіологічного вимірів. Наукова новизна. Автори обґрунтували доцільність та актуальність розгляду ідеї духовності в трилогії А. Азімова "Фундація" в смисловому полі філософської антропології. Показано, що філософська антропологія А. Азімова має чітко виражене телеологічне "навантаження". В інтерпретації письменника людина майбутнього – це не "постлюдина" зі зміненою за допомогою спеціальних технологій біологічною природою, а людина, орієнтована на духовний розвиток і самовдосконалення, що базуються на одвічних цінностях, зафіксованих у ментальному коді Homo sapiens – щасті, любові, свободі, гідності, незалежності, патріотизмі. Висновки. "Фундація" – твір багатоплановий, сюжетно насичений, композиційно мозаїчний, поліфонічний, у якому, на перший погляд, важко визначити якусь домінантну ідею. У процесі дослідження встановлено, що в творчості А. Азімова одним із основних змістових центрів є філософсько-антропологічний дискурс, у просторі якого значну увагу приділено духовності людини. (shrink)

Lectures based on the commentaries on Brahmasūtra of Bādarāyaṇa.